This page outlines the disadvantages of Soft-IVF when compared with conventional In Vitro Fertilization. The Soft-IVF Benefits page lists the advantages of Soft-IVF.
There are possible disadvantages of Soft-IVF when compared with conventional In Vitro Fertilization:
- Lower cumulative probability of pregnancy for most patients
Since Soft-IVF frequently results in the development of fewer embryos compared with conventional In Vitro Fertilization, most patients’ cumulative probability of pregnancy from Soft-IVF will be lower than the cumulative pregnancy probability of conventional In Vitro Fertilization.
- Risk of no embryos available for transfer
Not all developing ovarian follicles will have an egg in them, and not all eggs will successfully fertilize and develop into embryos. Since Soft-IVF treatment usually does not result in a very high number of follicles developing within the ovaries, there is a small risk that there may not be healthy embryos available for transfer into the uterus.
- Usually only a few extra Soft-IVF embryos available for multiple embryo transfers
Conventional In Vitro Fertilization will commonly result in one or two “fresh” embryos transferred inside the uterus and several extra embryos available for cryopreservation. Soft-IVF may yield only a very few embryos available for multiple embryo transfers.
- Increased cancelation rate due to premature ovulation
In conventional IVF, a series of shallow daily hormonal injections are used to prevent premature ovulation. These injections are not a part of the Soft-IVF treatment, and occasionally one or more ovarian follicles may ovulate spontaneously prior to egg retrieval.
- No “fresh” embryo transfer
Clomid medication used for Soft-IVF ovarian stimulation commonly causes thinning of the uterine lining (endometrium) reducing the probability of implantation. All Soft-IVF embryos must be cryopreserved (vitrified) and transferred as frozen-thawed embryos.
- Soft-IVF cannot be combined with sperm aspiration
Since Soft-IVF commonly does not result in the development of a high number of eggs, it is not combined with the sperm aspiration procedure.