Bay IVF - Advanced Reproductive Care                                Palo Alto  650-322-0500


Deciding between IVF and Soft-IVF

The majority of eligible patients will be candidates for both conventional In Vitro Fertilization and Soft-IVF.

The following table summarizes the differences between Soft-IVF and conventional IVF.

Soft-IVF and Conventional IVF
Treatment Comparison
  Soft-IVF Conventional
Estimated Live-Birth Probability
Per Embryo Transfer
  • Identical / similar
    (34 & younger: 43%
    35 to 37 years: 34%)
    38 to 40 years: 22%)
  • Identical / similar
    (34 & younger: 43%
    35 to 37 years: 34%)
    38 to 40 years: 22%)
Estimated Cumulative
Live-Birth Probability from
All Available Embryos
  • Will be lower on the average
    (fewer embryos available for repeated transfers)
  • Will be higher on the average
    (more embryos available for repeated transfers)
$9,460 $9,870
Cost of
  • Approx. $800
    (charged by a pharmacy)
  • Approx. $3,000
    (charged by a pharmacy)
  • 40 years and younger
  • 21 to 35-day menstrual cycles
  • AFC1 10 to 24
  • FSH 9.0 or less and E2 50 or less2
  • Min. sperm motility: 5%
  • Min. nl morphology: 5%3
  • 43 years and younger
  • Regular menstrual cycles are not required
  • AFC 4 or higher
  • FSH 12.0 or less and E2 90 or less depending on AFC
  • Any number of living sperm
  • Oral medications and approx. five tiny, shallow injections
  • One blood draw
  • Daily tiny, shallow injections for approx. four weeks
  • Approx. 5 blood draws
Egg Retrieval
  • Identical / similar
  • Identical / similar
Embryo Transfer4
  • Not done
  • Part of IVF treatment
Embryo Freezing
Frozen Embryo Transfer5
  • Required, included in cost
  • As needed, separate fee
Number of
Clinic Visits
  • Identical / similar
    (Approx. 4 to 6)
  • Identical / similar
    (Approx. 4 to 6)
Can Be Combined with Sperm Aspiration
  • No
  • Yes, if needed


1 You will have an ovarian ultrasound during your initial visit at Bay IVF to count the number of antral follicles, seen as small dark circles, within the ovaries (AFC, antral follicle count). The AFC is related to the quality of the eggs. Ideally, there should be approximately 20 antral follicles in both ovaries combined. Too few or too many antral follicles indicate that normal quality eggs may be infrequent or even absent within the ovaries.

There must be between 10 and 24 antral follicles in both ovaries combined for Soft-IVF. Women with too low or too high AFC do not properly respond to Soft-IVF ovarian stimulation. The majority of women will have 12 to 24 antral follicles.


2 FSH = follicle stimulating hormone, E2 = estradiol, estrogen

3 Since the average number of retrieved eggs is expected to be lower in the Soft-IVF treatment compared with conventional IVF, there must not be a major degree of male infertility present. The male partner must be able to produce a sufficient number of living sperm (total motility 5% or higher and normal sperm morphology 5% or higher in the preliminary semen analysis at Bay IVF). This minimizes the risk that none of the eggs will fertilize.

4 Clomid used for Soft-IVF ovarian stimulation can cause thinning of the uterine lining and reduce the probability of implantation. To correct for this Clomid side-effect, all Soft-IVF embryos are frozen (vitrified) and transferred inside the uterus in a subsequent frozen-thawed embryo transfer cycle.

5 Frozen embryo transfer

If you have any questions regarding the above information or need help deciding between IVF and Soft-IVF, please contact us by phone at 650-322-0500 or via email at

Please use the following links for additional information about Soft-IVF and to Request a consultation.


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with Dr. Polansky


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